HCID 21193996, compound → HCID 21193848, compound

HRID 1067470Notes

Reaction equation

HRID 1067470 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([C:9]2([C:12]3[CH:25]=[CH:24][C:15]([N:16](C(=O)C(F)(F)F)[CH3:17])=[C:14]([N+:26]([O-:28])=[O:27])[CH:13]=3)[CH2:11][CH2:10]2)=[O:8])[CH:2]=1>[OH-].[K+].C(O)(C)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([C:9]2([C:12]3[CH:25]=[CH:24][C:15]([NH:16][CH3:17])=[C:14]([N+:26]([O-:28])=[O:27])[CH:13]=3)[CH2:11][CH2:10]2)=[O:8])[CH:2]=1

Participants

4

Reactant 1

HCID 21193996HCID 21193996, compound

Product 1

HCID 21193848HCID 21193848, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 14797Potassium HydroxideSolvent

Procedure

7.4 g (18.8 mmol) of 4-[1-[(pyridin-3-yl)-carbonyl]cyclopropyl]-2-nitro-N-trifluoroacetyl-N-methyl-aniline are stirred in 200 ml of 20% potassium hydroxide solution for one hour at 30° C. Then the mixture is diluted with isopropanol, the organic phase is separated off, 10.0 g of aluminium oxide are added and the resulting mixture is evaporated to dryness. The residue is chromatographed on aluminium oxide, eluting with petroleum ether/ethyl acetate (4:1 and 1:1).

Workup

  1. customthe organic phase is separated off
  2. addition10.0 g of aluminium oxide are added
  3. customthe resulting mixture is evaporated to dryness
  4. customThe residue is chromatographed on aluminium oxide
  5. washeluting with petroleum ether/ethyl acetate (4:1 and 1:1)

Sources & evidence

ORD record
ord-caa4fc12d2814ce2b6ff9b1709f4e9bc
Source dataset
uspto-grants-2001_06
Patent number
US06248770B1

Reaction notes

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