Aniline → HCID 22386596, compound

HRID 1067490Notes

Reaction equation

HRID 1067490 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[NH2:10][C:11]1[N:20]=[C:19]([NH2:21])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2F)[N:12]=1>CS(C)=O>[NH2:10][C:11]1[N:20]=[C:19]([NH2:21])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:12]=1

Participants

5

Reactant 3

HCID 6115AnilineHCID 24758Sodium hydrideHCID 4562462,4-Quinazolinediamine, 5-fluoro-

Product 1

HCID 22386596HCID 22386596, compoundYield 4.8%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Aniline (Aldrich) (5 g, 50 mmol), sodium hydride (80% disp in mineral oil) (1.5 g, 50 mmol) and 2,4-diamino-5-fluoroquinazoline (4.4 g, 25 mmol) were reacted in 80 ml of dimethyl sulphoxide according to procedure A to give 2,4-diamino-5-anilinoquinazoline (0.3 g, 4.8%, m.p. 279-283° C. (dec)).

Sources & evidence

ORD record
ord-83479a61f3ec4ab0b3423a62074867d9
Source dataset
uspto-grants-2001_06
Patent number
US06248771B1

Reaction notes

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