Triethylamine → HCID 11831504, compound

HRID 1067593Notes

Reaction equation

HRID 1067593 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:16])([CH3:15])[C:12](O)=[O:13])[N:10]=2)[N:7]=1.[Cl-].[NH4+].C([N:21](CC)CC)C>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:16])([CH3:15])[C:12]([NH2:21])=[O:13])[N:10]=2)[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 11746720HCID 11746720, compound

Product 1

HCID 11831504HCID 11831504, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.20 g of 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionic acid was dissolved in 8 ml of N,N-dimethylformamide; 0.892 g of N,N′-carbonyldiimidazole was added, followed by stirring at room temperature for 30 minutes. To this mixture, 0.321 g of ammonium chloride and 0.832 ml of triethylamine were added under ice cooling conditions, followed by stirring at room temperature for 3 hours. Ice water was added to the reaction mixture; the crystal precipitated was collected by filtration, washed with water and dried to yield 0.697 g of the title compound.

Workup

  1. stirringby stirring at room temperature for 3 hours
  2. customthe crystal precipitated
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-8a90a1f206bd4de289da78ea7818424f
Source dataset
uspto-grants-2001_06
Patent number
US06248740B1

Reaction notes

Loading…