反应详情

4.07 g of ethyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate was suspended in 60 ml of ethyl acetate; 2.13 g of N-chlorosuccinimide was added, followed by thermal refluxing for 4 hours. After cooling, water was added, followed by extraction with ethyl acetate; the extract was washed with saturated saline and dried with magnesium sulfate. The dry product was concentrated under reduced pressure; the residue was subjected to silica gel column chromatography and eluted with hexane:ethyl acetate (5:1). The desired fraction was collected and concentrated under reduced pressure to yield 4.48 g of the title compound.

1. customrefluxing for 4 hours
2. temperatureAfter cooling
3. extractionfollowed by extraction with ethyl acetate
4. washthe extract was washed with saturated saline
5. dry with materialdried with magnesium sulfate
6. concentrationThe dry product was concentrated under reduced pressure
7. washeluted with hexane:ethyl acetate (5:1)
8. customThe desired fraction was collected
9. concentrationconcentrated under reduced pressure