Hydroxyamine hydrochloride → HCID 178526338, compound

HRID 1067713Notes

Reaction equation

HRID 1067713 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([CH:18]3[CH2:20][CH2:19]3)=O)=[CH:12][CH:11]=2)[N:3]=[CH:2]1.Cl.[NH2:22][OH:23]>C(O)C>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16](=[N:22][OH:23])[CH:18]3[CH2:20][CH2:19]3)=[CH:12][CH:11]=2)[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 178519714HCID 178519714, compound

Product 1

HCID 178526338HCID 178526338, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.2 mmol of cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl ketone (Example 61) and 2.4 mmol of hydroxylamine hydrochloride in 20 ml of anhydrous ethanol are heated at 60° C. for 5 hours. The mixture is treated as described in Example 138, but isolated in the form of the free base.

Workup

  1. additionThe mixture is treated
  2. customisolated in the form of the free base

Sources & evidence

ORD record
ord-18e746d78d67495187d34c35748db1d0
Source dataset
uspto-grants-2001_06
Patent number
US06248765B1

Reaction notes

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