Terazosin → Hydrochloric Acid

HRID 1067909Notes

Reaction equation

HRID 1067909 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14]([NH2:15])=[N:13][C:12]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([CH:24]4[O:28][CH2:27][CH2:26][CH2:25]4)=[O:23])[CH2:18][CH2:17]3)=[N:11][C:6]2=[CH:7][C:8]=1[O:9][CH3:10].[ClH:29].O.O>O>[ClH:29].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14]([NH2:15])=[N:13][C:12]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([CH:24]4[O:28][CH2:27][CH2:26][CH2:25]4)=[O:23])[CH2:18][CH2:17]3)=[N:11][C:6]2=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 2

HCID 5401Terazosin2×HCID 21899424Dihydrate;hydrochloride

Product 2

HCID 313Hydrochloric AcidHCID 5401Terazosin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Canadian Pat. No. 2,150,985 describes a process for preparing Terazosin.HCl dihydrate which initially involves the preparation of terazosin free base. The free base form is then reacted by suspension in water and the addition thereto of a molar equivalent of aqueous hydrochloric acid to produce Terazosin.HCl dihydrate.

Workup

  1. additionthe addition

Sources & evidence

ORD record
ord-4ee48d99bfdb44748505e57ed57c063c
Source dataset
uspto-grants-2001_06
Patent number
US06248888B1

Reaction notes

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