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HRID1067963

反应详情

EQUATION

反应方程式

HRID 1067963 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Br.CCN(CC)CCBr
HCID70607

2-Bromoethyldiethylammonium bromide

C6H15Br2N

结构：O=C(NCc1ccc(Cl)cc1)c1cnc2c(F)cc(C#CCO)cc2c1O
HCID178522909

未命名化合物

PRODUCTS

生成物

1
结构：CCN(CC)CCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(C#CCO)cc(F)c21
HCID16073830

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
95 °C

PROCEDURE

实验过程

A solution of N-(4-chlorobenzyl)-8-fluoro-4-hydroxy-6-(3-hydroxy-1-propynyl)-3-quinolinecarboxamide from Preparation No. 15 (0.96 g) is dissolved in DMF (7 mL), and K2CO3 (1.38 g) and 2-bromo-N,N-diethylethylamine hydrobromide (1.30 g) are added. The reaction mixture is heated to 95° C. for 16. Water is added and an oily solid formed, which is isolated by decanting the liquid. Column chromatography (elution with 1-3% MeOH/CHCl3) gave 0.373 g of the title compound which is crystallized from ethyl acetate to give 0.163 g of a solid.

WORKUP

后处理

  1. customan oily solid formed
  2. customwhich is isolated
  3. customby decanting the liquid
  4. washColumn chromatography (elution with 1-3% MeOH/CHCl3)