Triethylamine → (2S,9S)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

HRID 1068074Notes

Reaction equation

HRID 1068074 reaction equation
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3].[C:12]([O:16][C:17](=[O:37])[C@@H:18]([NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:19][CH2:20][CH2:21][CH2:22][NH:23][CH2:24][C@H:25]([OH:28])[CH2:26][Cl:27])([CH3:15])([CH3:14])[CH3:13].C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:12]([O:16][C:17](=[O:37])[C@@H:18]([NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:19][CH2:20][CH2:21][CH2:22][N:23]([C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3])[CH2:24][C@H:25]([OH:28])[CH2:26][Cl:27])([CH3:15])([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10387Benzyl chloroformateHCID 10810670(2S,9S)-2-[(tert-Butoxycarbonyl)amino]-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl Ester

Product 1

HCID 10792289(2S,9S)-2-[(tert-Butoxycarbonyl)amino]-7-(carbobenzyloxy)-10-chloro-9-hydroxy-7-azadecanoic Acid tert-Butyl EsterYield 93.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent3×

Procedure

A solution of benzyl chloroformate (1.21 g, 7.09 mmol) in chloroform (10 mL) was added over a period of 15 min to an ice-cold solution of 12a (2.16 g, 5.46 mmol) in chloroform (40 mL) under an Ar atmosphere. After dropwise addition of triethylamine (1.11 g, 11.0 mmol) in chloroform (10 mL), the reaction mixture was stirred for 4.5 hours at rt. The reaction mixture was extracted with 1 N HCl (60 mL) and water (60 mL), dried, and concentrated. The residue was purified by flash chromatography (33% ethyl acetate/hexane) to give 13a (2.69 g, 93%) as a colorless oil: 1H NMR 61.30-1.83 (m, 6H), 1.44 (s, 9H), 1.45 (s, 9H), 3.20-3.64 (m, 6H), 3.93 (dd, 1H, J=8.2; 5.5), 4.00 (m, 1H), 5.12 (s, 2H), 7.26-7.40 (m, 5H); 13C NMR δ 24.1, 28.3, 28.8, 32.5, 49.4, 51.4, 52.2, 55.7, 68.4, 71.0, 80.4, 82.5, 129.0, 129.1, 129.6, 138.0, 157.5-158.4 (br), 158.1, 173.7; HRMS m/z calcd for C26H42ClN2O7 529.2681, found 529.2694. Anal. calcd. for C26H41ClN2O7: C 59.03, H 7.81, N 5.29. Found: C 59.09, H 7.78, N 5.21. [α]23D−21.8° (c 1.00, CH3OH).

Workup

  1. extractionThe reaction mixture was extracted with 1 N HCl (60 mL) and water (60 mL)
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was purified by flash chromatography (33% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-0c6b9ff0f5754d428b15d2428fa82a44
Source dataset
uspto-grants-2001_06
Patent number
US06248866B1

Reaction notes

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