Ammonium formate → HCID 15549372, compound

HRID 1068151Notes

Reaction equation

HRID 1068151 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:23](=[O:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:23](=[O:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=[CH:15]2)[CH2:12][CH2:13]1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 9905121HCID 9905121, compound

Product 1

HCID 15549372HCID 15549372, compoundYield 82.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 100 mg of 3-(1-benzyl-piperidin-4-yl)-3-H-quinazolin-4-one (from Step B) in 6 mL of MeOH was added 100 mg of ammonium formate followed by 100 mg of 10% palladium on carbon. After refluxing for 5 hours, the mixture was filtered through celite. Concentration under reduced pressure afforded 59 mg of the title compound as a foamy solid.

Workup

  1. temperatureAfter refluxing for 5 hours
  2. filtrationthe mixture was filtered through celite
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-d6e425786d30406596dc48a821cc58de
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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