Thiobenzamide → HCID 21192967, compound

HRID 1068192Notes

Reaction equation

HRID 1068192 reaction equation
Br[CH2:2][C:3]([CH:5]1[CH2:10][CH2:9][N:8]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.[C:19]([NH2:27])(=[S:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CCO>[C:11]([N:8]1[CH2:9][CH2:10][CH:5]([C:3]2[S:26][C:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:27][CH:2]=2)[CH2:6][CH2:7]1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 683563ThiobenzamideHCID 21192975HCID 21192975, compound

Product 1

HCID 21192967HCID 21192967, compoundYield 32.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To 150 mg of 2-bromo-1-(1-benzoyl-4-piperidyl)-1-ethanone in 6 ml of EtOH was added 66 mg of thiobenzamide. The reaction was stirred at 80° C. for 2 hours. The solvent was evaporated under reduced pressure. The residue was purified by flash chromatography with 50% EtOAc in hexane to give 55 mg of the title compound.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was purified by flash chromatography with 50% EtOAc in hexane

Sources & evidence

ORD record
ord-e65d7f51cdc34b3ab31746dd6b02233e
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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