Hydrochloric Acid → HCID 70204643, compound

HRID 1068417Notes

Reaction equation

HRID 1068417 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@@H:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=2)[C@H:10]([OH:21])[CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:20][C:16]1[CH:15]=[C:14]([C@@H:11]2[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]2[OH:21])[CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70204515HCID 70204515, compound

Product 1

HCID 70204643HCID 70204643, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of trans -N-t-butoxycarbonyl-4-(3-methylphenyl)-3 hydroxypiperidine, (0.20 g, 0.12 mmol) in EtOAc (50 ml) at 0° C. was bubbled HCl gas until saturated. The reaction was stirred at 0° C. for 10 min and then the solvent evaporated in vacuo to afford the product as a white foam.

Workup

  1. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-4b488abd4dd141e6bc29b342b20dbff5
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

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