反应详情

温度

-78 °C

The product from Step D is dissolved in THF and cooled to −78° C. under nitrogen. A solution of LDA in THF is added dropwise. The reaction was stirred at −78° C. for 1 h, then a solution of 4-formyl-1-phenylpiperidine from Step A is added, and the reaction warmed to room temperature overnight. The reaction is quenched with ammonium chloride solution, and extracted with ethyl acetate. The title compound is obtained after chromatography on silica gel.

1. temperaturethe reaction warmed to room temperature overnight
2. customThe reaction is quenched with ammonium chloride solution
3. extractionextracted with ethyl acetate