Chlorosulfonyl isocyanate → HCID 54024967, compound

HRID 1068494Notes

Reaction equation

HRID 1068494 reaction equation
Cl[S:2]([N:5]=C=O)(=[O:4])=[O:3].[CH2:8]([N:15]1[CH2:20][CH2:19][C:18]([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)([CH2:21][NH2:22])[CH2:17][CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C1COCC1.C(O)=O>[CH2:8]([N:15]1[CH2:20][CH2:19][C:18]([CH2:21][NH:22][S:2]([NH2:5])(=[O:4])=[O:3])([NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH3:30])[CH:25]=2)[CH2:17][CH2:16]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 70918Chlorosulfonyl isocyanateHCID 21193317HCID 21193317, compound

Product 1

HCID 54024967HCID 54024967, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

To a cold (5° C.) solution of chlorosulfonyl isocyanate in THF, anhydrous formic acid is added (Journal of Organic Chemistry, vol 54, page 5825,(1989)). The resultant mixture is stirred until gas evolution ceased, and treated with a solution of 1-benzyl-4-(3-methylphenylamino)-4-aminomethylpiperidine in THF. The mixture is stirred at room temp. overnight to provide the title compound.

Sources & evidence

ORD record
ord-01dfed75a3444df3bf8603f5adc591fc
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

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