3-Aminopyridine → HCID 1704483, compound

HRID 1068952Notes

Reaction equation

HRID 1068952 reaction equation
CS[C:3]([S:9][CH3:10])=[C:4]([C:7]#[N:8])[C:5]#[N:6].[NH2:11][C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1>C1(C)C=CC=CC=1>[C:5]([C:4](=[C:3]([S:9][CH3:10])[NH:11][C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[C:7]#[N:8])#[N:6]

Participants

4

Reactant 2

HCID 100093-AminopyridineHCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrile

Product 1

HCID 1704483HCID 1704483, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 11 g (64.6 mmol) of 3,3-bis-methylmercapto-2-cyano-acrylonitrile, 6 g (63.75 mmol) of 3-amino-pyridine and 50 ml of toluene is stirred at 60° C. for 18 hours. Filtration of the reaction mixture while still warm and washing of the filter residue with toluene yield 2-cyano-3-methylmercapto-3-(3-pyridylamino)-acrylonitrile; m.p. 180-181° C.

Workup

  1. filtrationFiltration of the reaction mixture
  2. temperaturewhile still warm
  3. washwashing of the filter residue with toluene

Sources & evidence

ORD record
ord-eeaca6f19d884ffda3d65664fabcc352
Source dataset
uspto-grants-2001_06
Patent number
US06251911B1

Reaction notes

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