反应详情

温度

0 °C

A suspension of triphenylmethylphosphonium bromide (25.23 g) and potassium tert-butoxide (1M solution in tetrahydrofuran) (75.67 ml) was stirred at 0° C. for 0.5 h. A solution of 3-phenoxy-benzaldehyde (10.0 g) in THF (10 ml) was added to the mixture and the reaction mixture stirred at 0° C. for 4 h. Ammonium chloride solution was added and the mixture extracted with diethyl ether. The organic extracts were combined, washed with water, dried and concentrated. Purification (SiO2, isohexane:ethyl acetate 4:1 as eluant) gave the subtitle compound (7.12 g).

1. stirringthe reaction mixture stirred at 0° C. for 4 h
2. extractionthe mixture extracted with diethyl ether
3. washwashed with water
4. customdried
5. concentrationconcentrated
6. customPurification (SiO2, isohexane:ethyl acetate 4:1 as eluant)