HCID 77750336, compound → HCID 77750205, compound

HRID 1069036Notes

Reaction equation

HRID 1069036 reaction equation
[OH:1][CH2:2][CH:3]=[CH:4][CH:5]1[CH2:9][CH:8]([N:10]2[C:14]3[N:15]=[C:16]([S:29][CH2:30][CH2:31][CH3:32])[N:17]=[C:18]([NH:19][CH:20]4[CH2:22][CH:21]4[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[C:13]=3[N:12]=[N:11]2)[CH:7]([OH:33])[CH:6]1[OH:34]>O1CCCC1>[OH:1][CH2:2][CH2:3][CH2:4][CH:5]1[CH2:9][CH:8]([N:10]2[C:14]3[N:15]=[C:16]([S:29][CH2:30][CH2:31][CH3:32])[N:17]=[C:18]([NH:19][CH:20]4[CH2:22][CH:21]4[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[C:13]=3[N:12]=[N:11]2)[CH:7]([OH:33])[CH:6]1[OH:34]

Participants

3

Reactant 1

HCID 77750336HCID 77750336, compound

Product 1

HCID 77750205HCID 77750205, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the product of Example 53, step (c) (0.2 g) and triisopropylbenzenesulphonylhydrazide (0.3 g) in tetrahydrofuran (10 ml) was heated at 70° C. for 4 hours. The mixture was then purified (SiO2, ethyl acetate as eluant) to afford the title compound (0.13 g).

Workup

  1. customThe mixture was then purified (SiO2, ethyl acetate as eluant)

Sources & evidence

ORD record
ord-b5c86ab76f284c02b6cecf963cc6c111
Source dataset
uspto-grants-2001_06
Patent number
US06251910B1

Reaction notes

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