Hydrochloric Acid → Phenethylamine, N-methyl-, hydrochloride

HRID 1069116Notes

Reaction equation

HRID 1069116 reaction equation
[CH2:1](Br)C#C.C[CH:6]([NH2:14])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[ClH:15].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[ClH:15].[CH3:1][NH:14][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3007AmphetamineHCID 7842Propargyl bromideHCID 11430Potassium Carbonate

Product 1

HCID 77742Phenethylamine, N-methyl-, hydrochloride

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A solution of propargyl bromide (1.1 g, 9.1 mmol) in acetonitrile (8.5 ml) was added dropwise to a stirred mixture of 3-(N-Me, N-Et carbamyloxy)α-methyl phenethylamine.HCl (2.4 g, 8.8 mmol) and potassium carbonate (2.8 g) in acetonitrile (25 ml), and the mixture was stirred at RT for 7 hrs. The reaction mixture was filtered and the filtrate was removed under reduced pressure and the residue was purified by column chromatography (hexane:EtOAc 2:1) to give 1.76 g of the title compound as the free base (73%)

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was removed under reduced pressure
  3. customthe residue was purified by column chromatography (hexane:EtOAc 2:1)

Sources & evidence

ORD record
ord-e0209af03ab948a7b6533ff083cb6f04
Source dataset
uspto-grants-2001_06
Patent number
US06251938B1

Reaction notes

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