Lithium Hydroxide → HCID 21191395, compound

HRID 1069160Notes

Reaction equation

HRID 1069160 reaction equation
[NH2:1][C:2]([NH:4][C:5]1[CH:6]=[C:7]([C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][C:22]([O:24]CC)=[O:23])=[CH:16][CH:15]=2)=[O:12])[CH:8]=[CH:9][CH:10]=1)=[O:3].[Li+].[OH-]>CO.O.C(O)(C(F)(F)F)=O>[NH2:1][C:2]([NH:4][C:5]1[CH:6]=[C:7]([C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])=[CH:16][CH:15]=2)=[O:12])[CH:8]=[CH:9][CH:10]=1)=[O:3]

Participants

6

Reactant 2

HCID 3939Lithium HydroxideHCID 21191439HCID 21191439, compound

Product 1

HCID 21191395HCID 21191395, compound

Reagents, catalysts & solvents 3

HCID 6422Trifluoroacetic acidCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

The Compound of Example 22 (0.12 g, 0.34 mmol) was dissolved in MeOH (2 mL) and 1 M LiOH (1 mL) was added. The reaction was stirred at room temperature over 16 hours. The reaction was concentrated in vacuo to give a white solid. The solid was dissolved in a small amount of H2O and acidified with 1 drop of TFA. The mixture was concentrated in vacuo and the residue was purified by HPLC—Method 1 to give a white solid (0.06 g,).

Workup

  1. concentrationThe reaction was concentrated in vacuo
  2. customto give a white solid
  3. concentrationThe mixture was concentrated in vacuo
  4. customthe residue was purified by HPLC—Method 1
  5. customto give a white solid (0.06 g,)

Sources & evidence

ORD record
ord-1f4e5ef2431d4447a1e4878e30b9a452
Source dataset
uspto-grants-2001_06
Patent number
US06251944B1

Reaction notes

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