反应详情

温度

60 °C

Benzyl bromide (0.73 ml, 2.50 equivalents) was added to 4.24 g of an acetonitrile solution containing 1.0 g (corresponding to 2.45 mmols) of triacetylguanosine obtained in Example 1, and the mixture was stirred at 60° C. for 19 hours. The temperature was returned to room temperature, and 2.1 ml (10 equivalents) of conc. hydrochloric acid were added thereto. The mixture was reacted for 2 hours. The solid was precipitated in 1.5 hours. Ten milliliters of methanol were added thereto, and the slurry was stirred for 2 hours, and then filtered. The crystals were washed twice with 5 ml of methanol, and dried at 55° C. under reduced pressure for 3 hours to give 0.61 g of 7-benzylguanine in a yield of 79.2%.

1. customwas returned to room temperature
2. customThe mixture was reacted for 2 hours
3. customThe solid was precipitated in 1.5 hours
4. additionTen milliliters of methanol were added
5. stirringthe slurry was stirred for 2 hours
6. filtrationfiltered
7. washThe crystals were washed twice with 5 ml of methanol
8. customdried at 55° C. under reduced pressure for 3 hours