反应详情

Four milliliters of acetonitrile and 0.59 ml (2.7 equivalents) of benzyl bromide were added to 0.755 g (1.84 mmols) of triacetylguanosine, and the mixture was reacted at 50° C. for 16 hours. Subsequently, 2.5 ml (16.1 equivalents) of conc. hydrochloric acid were added thereto. The reaction was conducted at 50° C. for 50 minutes, and the temperature was then returned to room temperature. Then, the solid was precipitated. Fifteen milliliters of methanol were added thereto, and the slurry was stirred for 1 hour, and then filtered. The crystals were washed twice with 5 ml of methanol, and dried at 50° C. under reduced pressure for 2 hours to give 0.496 g of 7-benzylguanine crystals in a yield of 85.8%.

1. customthe mixture was reacted at 50° C. for 16 hours
2. customwas then returned to room temperature
3. customThen, the solid was precipitated
4. additionFifteen milliliters of methanol were added
5. filtrationfiltered
6. washThe crystals were washed twice with 5 ml of methanol
7. customdried at 50° C. under reduced pressure for 2 hours