反应详情

A solution of 3.8 g (146 mmol) of 2-cyclopropyl-5-methoxyl-1H-indole-3-acetic acid methyl ester in 50 mL of DMF was treated with 0.59 g (0146 mol) of 60% NaH/mineral oil, stirred 0.5 hour, and 1.69 mL (146 mmol) of benzyl chloride added. After 20 hours, the reaction mixture was diluted with water, extracted with EtOAc, the EtOAc solution was washed four times with water and dried over Na2SO4. After concentrating at reduced pressure, the product was purified by chromatography on silica, eluting with a gradient, 5% EtOAc/toluene→15% EtOAc/toluene, to give 2.05 g (40% yield) of 2-cyclopropyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid methyl ester as an oil.

1. waitAfter 20 hours
2. extractionextracted with EtOAc
3. washthe EtOAc solution was washed four times with water
4. dry with materialdried over Na2SO4
5. concentrationAfter concentrating at reduced pressure
6. customthe product was purified by chromatography on silica
7. washeluting with a gradient, 5% EtOAc/toluene→15% EtOAc/toluene