反应详情

To a solution of ethyl 5-bromo-benzofuran-2-carboxylate (5 g; 18.6 mmol) in 65 mL THF under nitrogen, was added DIBAL (46 mL, 46 mmol) dropwise over 30 minutes, then stirred overnight at room temperature. After dropwise addition of 25 mL of water, the mixture was evaporated, extracted with ethyl acetate, filtered, washed, dried (MgSO4) and evaporated to yield 4.2 g of crude product which was further purified by chromatography to afford (5-bromo-benzofuran-2-yl)-methanol.

1. customthe mixture was evaporated
2. extractionextracted with ethyl acetate
3. filtrationfiltered
4. washwashed
5. dry with materialdried (MgSO4)
6. customevaporated
7. customto yield 4.2 g of crude product which
8. customwas further purified by chromatography