Hydrochloric Acid → HCID 69755418, compound

HRID 1070435Notes

Reaction equation

HRID 1070435 reaction equation
C([NH:8][C@H:9]([C:27]([O:29][CH3:30])=[O:28])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N+:24]([O-:26])=[O:25])=[CH:13][CH:12]=1)(OC(C)(C)C)=O.[ClH:31]>C(OCC)(=O)C>[ClH:31].[CH3:30][O:29][C:27](=[O:28])[C@H:9]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[N+:24]([O-:26])=[O:25])=[CH:15][CH:16]=1)[NH2:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131724970HCID 131724970, compound

Product 1

HCID 69755418HCID 69755418, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-Boc-4-(2-nitrophenoxy)-(L)-phenylalanine, methyl ester (600 mg) was stirred in a solution of 1N hydrochloric acid in ethyl acetate (10 mL) for 18 hours at room temperature. A precipitate formed, the solvent was removed by rotoevaporation, and co-evaporated with Et2O (2×). The solid was than suspended with ethyl acetate, filtered, washed with diethyl ether, and allowed to air dry. The title compound was recovered (490 mg) and used in the subsequent reaction without further purification.

Workup

  1. customA precipitate formed
  2. customthe solvent was removed by rotoevaporation
  3. filtrationfiltered
  4. washwashed with diethyl ether
  5. customto air dry
  6. customThe title compound was recovered (490 mg)
  7. customused in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-eda0c4249bb0475381d0e83c5b582777
Source dataset
uspto-grants-2005_06
Patent number
US06903075B1

Reaction notes

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