反应详情

A solution of 3,4-dichlorobenzyl chloride (2.8 ml), 4-ketopiperidine hydrochloride monohydrate and triethylamine (8 ml) in dimethylformamide (30 ml) was stirred at room temperature for 20 h. The mixture was partitioned between water and ethyl acetate, the organic layer dried and evaporated under reduced pressure. Purification was by chromatography eluting with 40-50% ethyl acetate/isohexane. Yield 2.1 g.

1. customThe mixture was partitioned between water and ethyl acetate
2. customthe organic layer dried
3. customevaporated under reduced pressure
4. customPurification
5. washeluting with 40-50% ethyl acetate/isohexane