Succinic anhydride → 3-[3-(2-pyridinyl)-1H-1,2,4-triazol-5-yl]propanoic acid

HRID 1070504Notes

Reaction equation

HRID 1070504 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7](=[N:9][NH2:10])[NH2:8].[O:11]1[C:15](=O)[CH2:14][CH2:13][C:12]1=[O:17]>CC(N(C)C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:8]=[C:15]([CH2:14][CH2:13][C:12]([OH:17])=[O:11])[NH:10][N:9]=1

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 70493Picolinimidohydrazide

Product 1

HCID 223961833-[3-(2-pyridinyl)-1H-1,2,4-triazol-5-yl]propanoic acid

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent2×

Procedure

2-Pyridinecarbohydrazonamide (0.136 g) and dihydro-2,5-furandione (0.100 g) in 1 ml of dimethylacetamide was heated for 10 times 30 seconds in a CEM MARS 5 microwave at 100% of 300 W under nitrogen to leave 3-[3-(2-pyridinyl)-1H-1,2,4-triazol-5-yl]propanoic acid in 1 ml of dimethylacetamide.

Sources & evidence

ORD record
ord-8f4d74c2f09646599c8c7db03cb7bd07
Source dataset
uspto-grants-2005_06
Patent number
US06903085B1

Reaction notes

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