反应详情

To a solution of 3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-propionic acid (1 g) in tetrahydrofuran (5 ml), was added carbonyldiimidazole (0.74 g). The mixture was stirred for 10 minutes before addition of 1-benzyl-piperidin-4-ylamine (1 ml) in tetrahydrofuran (5 ml). The reaction mixture was stirred for 15 minutes then partitioned between ethyl acetate (20 ml) and water (20 ml). The organic layer was separated, dried (MgSO4) and solvent removed by evaporation. Purification by Biotage® 40S eluting 3%MeOH/0.5% 880 ammonia/dichloromethane gave the title compound (0.93 g).

1. customthen partitioned between ethyl acetate (20 ml) and water (20 ml)
2. customThe organic layer was separated
3. dry with materialdried (MgSO4) and solvent
4. customremoved by evaporation
5. customPurification by Biotage® 40S
6. washeluting 3%MeOH/0.5% 880 ammonia/dichloromethane