HRID1070522

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

HCID3164328

3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)propanoic acid

C10H9N3O3

HCID68884300

未命名化合物

PRODUCTS

生成物

结构：CC(c1ccc(Br)cc1)N1CCC(NC(=O)CCc2nc(-c3ccccn3)no2)CC1

HCID22396180

未命名化合物

收率 5.8%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

PROCEDURE

实验过程

Prepared following a method as hereinbefore described using (R)-1-[1-(4-bromophenyl)ethyl]-4-piperidinamine (449 mg), 3-(2-pyridinyl)-1,2,4-oxadiazole-5-propanoic acid (0.31 g), 1-hydroxybenzotriazole (0.20 g), 4-(N,N-dimethylamino)-pyridine (0.13 g) and 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide hydrochloride (0.30 g) to give the title compound (40 mg). m.p. 153-155° C.

WORKUP

后处理

customPrepared