反应详情

温度

100 °C

To a solution of 4-nitro-2,3-dihydro-1H-isoindol-1-one (compound 3, 3.2 gm, 0.018 mmol.) in DMF (10 ml), was added ammonium formate (5.750 gm), and Pd—C (100 mg), and the reaction mixture was stirred at 100° C. for 30 min. The mixture was then filtered through a pad of celite, and the celite was washed with DMF (10 ml) and water (10 ml). The filtrate was concentrated under vacuum to give compound 4 (2.2 gm, 83%).

1. filtrationThe mixture was then filtered through a pad of celite
2. washthe celite was washed with DMF (10 ml) and water (10 ml)
3. concentrationThe filtrate was concentrated under vacuum