反应详情

To a solution of 4-hydroxy 2,3-dihydro-1H-isoindol-1-one (27) (0.250 gm, 1.67 mmol) in DMF (5 ml) K2CO3 and was added, followed by addition of methyl bromoacetate, and the reaction mixture was stirred at room temperature for 2 hr. Then the reaction mixture was then poured on ice and extracted with ethyl acetate (2×15 ml). After the standard workup, the residue was dissolved in methanol (3 ml), and treated with NaOH (5 ml, 1N) at 0° C. and then stirred for and additional hour. After the standard workup, the solid was recrystalized in methanol to give compound 29 (0.140 gm, 60%).

1. additionThen the reaction mixture was then poured on ice
2. extractionextracted with ethyl acetate (2×15 ml)
3. dissolutionAfter the standard workup, the residue was dissolved in methanol (3 ml)
4. additiontreated with NaOH (5 ml, 1N) at 0° C.
5. stirringstirred for and additional hour
6. customAfter the standard workup, the solid was recrystalized in methanol