Ethyl Acrylate → HCID 22397321, compound

HRID 1070563Notes

Reaction equation

HRID 1070563 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH:8]1([NH2:11])[CH2:10][CH2:9]1.[CH:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]>C(OCC)(=O)C.CCCCCCC>[C:15]([O:14][C:12]([N:11]([CH:8]1[CH2:10][CH2:9]1)[CH2:3][CH2:2][C:1]([O:5][CH2:6][CH3:7])=[O:4])=[O:13])([CH3:18])([CH3:17])[CH3:16]

Participants

5

Reactant 3

HCID 8821Ethyl AcrylateHCID 61207tert-Butyl FormateHCID 69828Cyclopropylamine

Product 1

HCID 22397321HCID 22397321, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared from ethyl acrylate (1.09 ml, 10 mmol) and cyclopropylamine (0.69 ml, 10 mmol) according to Example 2a. Yield: 2.06 g (80%). ESI-MS: 258.2 (M+H)+, 202.2 (M+H—C4H8)+, 158.2 (M+H-Boc)+. Rf (silica gel; ethyl acetate/heptane, 1:4, v/v): 0.38.

Sources & evidence

ORD record
ord-e8a5361276bc4c369e16d7482d0da95a
Source dataset
uspto-grants-2005_06
Patent number
US06903107B1

Reaction notes

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