Hydrazine hydrate (1:1) → 4-[1,1′-Biphenyl]-2-yl-1-piperazinebutanamine

HRID 1070771Notes

Reaction equation

HRID 1070771 reaction equation
[C:1]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][N:17]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:9][CH2:8]1.O.NN>C(O)C>[C:1]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:15][CH2:16][NH2:17])[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22397693HCID 22397693, compound

Product 1

HCID 223976144-[1,1′-Biphenyl]-2-yl-1-piperazinebutanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Batch size: 20.8 g (47.3 mol) 2-[4-(4-biphenyl-2-yl-piper-azin-1-yl)-butyl]-isoindolin-1,3-dione and 4.6 ml (94.6 mmol) hydrazine-hydrate in 185 ml ethanol.

Sources & evidence

ORD record
ord-bbf3d6618f4d4922ae652a6342194fe8
Source dataset
uspto-grants-2005_06
Patent number
US06903118B1

Reaction notes

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