Thiophenol → tert-butyl 6-[2-(phenylsulfanyl)ethyl]-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate

HRID 1071065Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1071065
O[CH2:2][CH2:3][N:4]1[C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]2[CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:16][CH2:17][C:5]1=2.CS(Cl)(=O)=O.[C:30]1([SH:36])[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.[OH-].[K+]>C(Cl)Cl.CN(C=O)C.C(N(CC)CC)C>[C:30]1([S:36][CH2:2][CH2:3][N:4]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[C:6]3[CH2:13][CH2:14][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:16][CH2:17][C:5]2=3)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Komponenten

8

Edukt 4

HCID 7969ThiophenolHCID 14797Potassium HydroxideHCID 31297Methanesulfonyl chloride2×HCID 22396751tert-butyl 6-(2-hydroxyethyl)-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate

Produkt 1

HCID 22396645tert-butyl 6-[2-(phenylsulfanyl)ethyl]-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylateAusbeute 28 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

tert-Butyl 6-(2-hydroxyethyl)-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate, (0.0488 g, 0. 148 mmol) was dissolved in CH2Cl2 (5 mL) and stirred at rt. Triethylamine (5 mL) was added, followed by methanesulfonyl chloride (0.017 mL, 0.221 mmol, 1.50 equiv.). The reaction mixture was stirred for 2 h, and additional methanesulfonyl chloride (0.015 mL) was added. After 30 min, a mixture of thiophenol (0.065 mL, 0.592 mmol, 4.0 equiv.) and KOH (12 equiv.) in DMF (5 mL) was added, and the resulting mixture was stirred for 30 min. The reaction mixture was quenched with saturated aqueous NH4Cl, then the resulting mixture was extracted with CH2Cl2 (3×). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The crude product was purified by PTLC (1 mm×20 cm×20 cm SiO2 plates, developed with 1:4 EtOAc:bexane) to give tert-butyl 6-[2-(phenylsulfanyl)ethyl]-1,4,5,6-tetrahydroazepino[4,5-b]indole-3(2H)-carboxylate (0.017 g) in 28% yield as a white solid. 1H NMR (300 MHz, CDCl3) δ 1.52, 2.92, 2.99, 3.17, 3.66-3.73, 4.28, 7.10-7.20, 7.25-7.41, 7.48; MS (ESI+) for C25H30N2O2S m/z 423 (M+H)+.

Aufarbeitung

  1. stirringThe reaction mixture was stirred for 2 h
  2. additionwas added
  3. stirringthe resulting mixture was stirred for 30 min
  4. customThe reaction mixture was quenched with saturated aqueous NH4Cl
  5. extractionthe resulting mixture was extracted with CH2Cl2 (3×)
  6. dry with materialThe combined organic extracts were dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated
  9. customThe crude product was purified by PTLC (1 mm×20 cm×20 cm SiO2 plates, developed with 1:4 EtOAc:bexane)

Quellen und Nachweise

ORD-Eintrag
ord-37400916bbeb4e33aca903fdfc6d7a51
Quelldatensatz
uspto-grants-2005_06
Patentnummer
US06903090B2

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