Hydrogen Peroxide → [2-(dimethylamino)-3-pyridinyl]methanol(SALTDATA: HCl)

Temperature

0 °C

To a cold (ca. −78° C.) solution of 2.9 g (21 mmole) of 3-methyl-2-(N,N-dimethylamino)pyridine in 35 ml of tetrahydrofuran was added dropwise 15 ml (23 mmole) of 1.55 M butyllithium in hexane. The mixture was stirred at 0° C. for four hours and then recooled to ca. −78° C. Trimethyl borate (2.65 ml, ca. 23 mmole) was added dropwise and the mixture was stirred at 0° C. After one hour 2.9 ml of 30% hydrogen peroxide was added and the mixture was stirred at 25° C. After another hour, the reaction mixture was poured into water and extracted with several portions of diethyl ether. The combined ether extracts were dried over magnesium sulfate, filtered, and concentrated in vacuo to an oil. Chromatography on silica gel (using ethanol-toluene as eluent) yielded 600 mg of 3-hydroxymethyl-2-(N,N-dimethylamino)pyridine, as confirmed by the nmr and infrared spectra. Using the method of Example 79 with 3-hydroxymethyl-2-(N,N-dimethylamino) pyridinamine instead of 3-hydroxymethyl-2-pyridinamine yielded the title compound, which was used in subsequent reactions without further purification. Structure assignment was supported by the nmr and infrared spectra.

1. customrecooled to ca. −78° C
2. stirringthe mixture was stirred at 0° C
3. stirringthe mixture was stirred at 25° C
4. waitAfter another hour
5. extractionextracted with several portions of diethyl ether
6. dry with materialThe combined ether extracts were dried over magnesium sulfate
7. filtrationfiltered
8. concentrationconcentrated in vacuo to an oil

ORD record

ord-f9cc29253bab44c9a1012df11c3ea181

Source dataset

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06906078B2