3,5-Dichloroaniline → Benzamide

HRID 1071581Notes

Reaction equation

HRID 1071581 reaction equation
ClC1C=C(C=C(Cl)C=1)N.N[C:11]1[CH:12]=[C:13]([CH:25]=[CH:26][C:27]=1OC)[C:14]([NH:16]C1C=CC(F)=C(F)C=1)=[O:15]>>[C:14]([NH2:16])(=[O:15])[C:13]1[CH:25]=[CH:26][CH:27]=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 122813,5-DichloroanilineHCID 10755041HCID 10755041, compound

Product 1

HCID 2331BenzamideYield 5.9%

Procedure

The title compound was synthesized in the same manner as Example 1 using 3,5-dichloroaniline (1.0 g, 6.2 mmol), CSI (0.64 mL, 4.4 mmol), and 3-amino-N-(3,4-difluoro-phenyl)-4-methoxy-benzamide (1.24 g, 7.0 mmol) to give 0.05 g of pure benzamide, 3-[[[[[(3,5-dichlorophenyl)amino]-carbonyl]amino]sulfonyl]amino]-N-(3,4-difluorophenyl)-4-methoxy-. Microanalysis: C21H16Cl2F2N4O5S; calculated: C=46.25; H=2.96; N=10.27; found: C=46.30; H=3.32; N=9.93. MS: M++1=544.9 Da.

Sources & evidence

ORD record
ord-7cec6e89d08b4950831a1cff8f7dc0ba
Source dataset
uspto-grants-2005_06
Patent number
US06906094B2

Reaction notes

Loading…