HCID 20800783, compound → HCID 11436230, compound

HRID 1071611Notes

Reaction equation

HRID 1071611 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH2:14][CH2:15][CH2:16][OH:17])=[CH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>CO.O=[Pt]=O>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][OH:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 20800783HCID 20800783, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11436230HCID 11436230, compoundYield 68.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

6.48 g of 1-benzyl-4-hydroxypropyl-1,2,5,6-tetrahydropyridine was dissolved in 60 ml of methanol, 88 mg of PtO2 was added, and atmosphere was replaced with hydrogen. After completion of the reaction, the mixture was filtered, and the filtrate was evaporated, to give 4.50 g (19.3 mmol, 68.9%) of the title compound as a yellow oil.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe mixture was filtered
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-e45f52124a1b4fef963713051a71173c
Source dataset
uspto-grants-2005_06
Patent number
US06906072B1

Reaction notes

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