反应详情

Potassium tert-butoxide (35 mg) was suspended in DMF (5 ml), and a DMF solution (5 ml) of 3-cyano-5-(1-cyano-2-methylpropyl]thiophene (0.60 g) was added thereto. After stirring at room temperature for 3.5 hours, ethyl acetate was added. The mixture was washed with an aqueous saturated ammonium chloride and further brine, dried over anhydrous magnesium sulfate and then evaporated. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate system) to give the title compound as a pale yellow oil (0.55 g, 60%).

1. washThe mixture was washed with an aqueous saturated ammonium chloride and further brine
2. dry with materialdried over anhydrous magnesium sulfate
3. customevaporated
4. customThe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate system)