Triethylamine → HCID 20801233, compound

HRID 1071669Notes

Reaction equation

HRID 1071669 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][CH:21]=1)[CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[C:8]1[C:16](O)=[O:17].CCN(CC)CC.C1N(P(Cl)(N2C(=O)OCC2)=O)C(=O)OC1.[I:44][C:45]1[CH:50]=[CH:49][C:48]([NH2:51])=[CH:47][CH:46]=1>C(Cl)Cl>[I:44][C:45]1[CH:50]=[CH:49][C:48]([NH:51][C:16]([C:8]2[N:7]([CH2:6][C:5]3[CH:19]=[CH:20][CH:21]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:15]3[C:10]([CH:9]=2)=[CH:11][CH:12]=[CH:13][CH:14]=3)=[O:17])=[CH:47][CH:46]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 108934-IodoanilineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 223944531-[(3-Methoxyphenyl)methyl]-1H-indole-2-carboxylic acid

Product 1

HCID 20801233HCID 20801233, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 500 mg 1-(3-Methoxy-benzyl)-1H-indole-2-carboxylic acid in 8 ml DCM and 0.9 NEt3 452 mg, BOP-Cl was added at RT and the mixture was stirred for 30 min. After addition of 583 mg 4-Iodo-phenylamine the mixture was stirred for 16 h. Then the solvent was removed under reduced pressure to yield a white precipitate, which was washed with 1 ml MeOH/DCM 1:1.

Workup

  1. stirringwas stirred for 16 h
  2. customThen the solvent was removed under reduced pressure
  3. customto yield a white precipitate, which
  4. washwas washed with 1 ml MeOH/DCM 1:1

Sources & evidence

ORD record
ord-a7c2f88371f04922b1e78e9958c58929
Source dataset
uspto-grants-2005_06
Patent number
US06906084B2

Reaction notes

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