Diisopropylethylamine → HCID 69748139, compound

HRID 1071829Notes

Reaction equation

HRID 1071829 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[C:17]([F:19])[CH:18]=1)[CH2:5][C@H:6]([NH2:15])[C@@H:7]([OH:14])[C@@H:8]([OH:13])[CH2:9][CH2:10][CH2:11][CH3:12].[CH3:20][C:21]1[CH:22]=[C:23]([C:30]([N:32]([CH2:36][CH2:37][CH3:38])[CH2:33][CH2:34][CH3:35])=[O:31])[CH:24]=[C:25]([CH:29]=1)[C:26](O)=[O:27].[CH3:39]CN(C(C)C)C(C)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[C:17]([F:19])[CH:18]=1)[CH2:5][C@H:6]([NH:15][C:26](=[O:27])[C:25]1[CH:29]=[C:21]([CH3:20])[CH:22]=[C:23]([C:30]([N:32]([CH2:36][CH2:37][CH3:38])[CH2:33][CH2:34][CH3:35])=[O:31])[CH:24]=1)[C@@H:7]([OH:14])[C@@H:8]([OH:13])[CH2:9][CH2:10][CH2:11][CH2:12][CH3:39]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 113913935-methyl-N,N-dipropylisophthalamic acidHCID 59067291HCID 59067291, compound

Product 1

HCID 69748139HCID 69748139, compound

Procedure

The hydrochloride salt of (1S,2R,3S)-1-(3,5-difluorobenzyl)-2,3-dihydroxyheptylamine (0.1 mmol) was reacted with 5-methyl-N,N-dipropyl-isophthalamic acid as described in method A (addition of an extra equivalent of DIEA to neutralize the amine salt) to give N1-[(1S,2R,3S)-1-(3,5-difluorobenzyl)-2,3-dihydroxy-octyl]-5-methyl-N3,N3-dipropyl-isophthalamide. MS (ESI+) for C29H40F2N2O4 m/z 540.9 (M+Na)+.

Sources & evidence

ORD record
ord-7c9fb2eb34ea43058d6ca7a19b87adb7
Source dataset
uspto-grants-2005_06
Patent number
US06906104B2

Reaction notes

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