Hydrochloric Acid → 2-[4-(4H-1,2,4-Triazol-4-yl)phenyl]ethan-1-amine

HRID 1071970Notes

Reaction equation

HRID 1071970 reaction equation
[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C)=[CH:8][CH:7]=2)[CH:5]=1.Cl>CCOC(C)=O>[N:1]1[N:2]=[CH:3][N:4]([C:6]2[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][NH2:14])=[CH:10][CH:11]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22390700HCID 22390700, compound

Product 1

HCID 223907132-[4-(4H-1,2,4-Triazol-4-yl)phenyl]ethan-1-amine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A suspension of tert-butyl 2-[4(4H-1,2,4-triazol-4-yl)phenyl]ethylcarbamate (250 mg, 0.87 mmol) in EtOAc (4 mL) at 0° C. was saturated with HCl(g). After stirring at 0° C. for two hours, the reaction was concentrated to give 2-[4-(4H-1,2,4-triazol-4-yl)phenyl]ethanamine, which was used without further purification. LCMS (ES) 189.3 m/z (M+H)+.

Workup

  1. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-2bd7abca108e4689852c2d0a9a68607a
Source dataset
uspto-grants-2005_06
Patent number
US06908921B2

Reaction notes

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