Piperidine → 4-Piperidinylbut-1-ene

HRID 1072041Notes

Reaction equation

HRID 1072041 reaction equation
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21241Homoallyl bromide

Product 1

HCID 45622824-Piperidinylbut-1-eneYield 93.4%

Procedure

4-Bromobut-1-ene (1.35 g) was treated with piperidine (1.7 g) and heated at reflux for 3 hours. The mixture was cooled to ambient temperature, filtered and the residue washed with ether (50 mL). The combined filtrate and washings were evaporated to give the title compound (1.3 g).

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. filtrationfiltered
  4. washthe residue washed with ether (50 mL)
  5. customThe combined filtrate and washings were evaporated

Sources & evidence

ORD record
ord-2abbff9c572e4f08a048bf11c5ba08aa
Source dataset
uspto-grants-2005_06
Patent number
US06908929B2

Reaction notes

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