反应详情

温度

177.5 °C

A mixture of 5-(4-chloro-6-oxo-6.7-dihydro-pyrrolo[2,3-d]pyrimidin-5-ylidenemethyl)-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide, 1-benzyl-1H-indol-5-ylamine and p-toluenesulfonic acid (5 mg) in 2 mL of 1-methyl-2-pyrrodinone and 2-methoxyethyl ether (1:3) was heated at 170-185° C. for 7 to 15 hours. The reaction mixture was evaporated to dryness and purified by reversed phase HPLC, then dissolved in 2N HCl and acetontrile and freeze-dried to give 13.5 mg (42%) of the title compound. MS 589.3 [M++1].

1. customThe reaction mixture was evaporated to dryness
2. custompurified by reversed phase HPLC
3. dissolutiondissolved in 2N HCl
4. customacetontrile and freeze-dried