反应详情

温度

90 °C

The mixture of 5-chloro-7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidine (57.94 mg, 0.2 mmol), 4-aminomethylpyridine (23.79 mg, 0.22 mmol), and diisopropylethylamine (38.78, 0.3 mmol) in 2-propanol was stirred at 90° C. for 20 h, and cooled to room temperature. The solvent was evaporated, and 5 ml of ice water was added. Then the resulting product was extracted with 2×10 ml of ethyl acetate. The combined extract was dried over MgSO4. Then the solvent was evaporated and 2 ml of ether was added. The produced solid was collected by filtration and dried to give pure product (38 mg, 52.6%) of [7-(3,4-dimethoxy-phenyl)-imidazo[1,2-c]pyrimidin-5-yl]pyridin-4-ylmethyl-amine.

1. temperaturecooled to room temperature
2. customThe solvent was evaporated
3. addition5 ml of ice water was added
4. extractionThen the resulting product was extracted with 2×10 ml of ethyl acetate
5. extractionThe combined extract
6. dry with materialwas dried over MgSO4
7. customThen the solvent was evaporated
8. addition2 ml of ether was added
9. filtrationThe produced solid was collected by filtration
10. customdried