4-Bromophenacyl bromide → 1-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanone

HRID 1072505Notes

Reaction equation

HRID 1072505 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[CH2:4][NH:5][CH3:6].Br[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=1)=[O:15]>>[Br:22][C:19]1[CH:20]=[CH:21][C:16]([C:14](=[O:15])[CH2:13][N:5]([CH2:4][C:3]2[CH:7]=[CH:8][C:9]([Cl:11])=[CH:10][C:2]=2[Cl:1])[CH3:6])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 74544-Bromophenacyl bromideHCID 485424Benzenemethanamine, 2,4-dichloro-N-methyl-2×

Product 1

HCID 223868281-(4-Bromophenyl)-2-((2,4-dichlorobenzyl)(methyl)amino)ethanoneYield 69%

Procedure

(2,4-Dichloro-benzyl)-methyl-amine (see example 1, intermediate 1) and 2-bromo-1-(4-bromo-phenyl)-ethanone was reacted in analogy to the method described in example 1, intermediate 3. After analogous workup and chromatography on silica gel, the alkylation product was isolated in a yield of 69%.

Workup

  1. customAfter analogous workup and chromatography on silica gel, the alkylation product was isolated in a yield of 69%

Sources & evidence

ORD record
ord-cd5a889ac9fd4955a4c6abb498a7a24c
Source dataset
uspto-grants-2005_06
Patent number
US06911453B2

Reaction notes

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