Ethanesulfonyl chloride → HCID 131725015, compound

HRID 1072520Notes

Reaction equation

HRID 1072520 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([NH2:20])[CH:17]=[CH:18][CH:19]=1.[CH2:21]([S:23](Cl)(=[O:25])=[O:24])[CH3:22]>N1C=CC=CC=1.CN(C1C=CN=CC=1)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([NH:20][S:23]([CH2:21][CH3:22])(=[O:25])=[O:24])[CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 98361943-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)aniline

Product 1

HCID 131725015HCID 131725015, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1049PyridineSolvent

Procedure

307.1 mg (1 mmol) of the compound of example 35 was dissolved in 10 ml of pyridine and at 0° C., 0.19 g (1.5 mmol) of ethanesulfonyl chloride, and a catalytic amount of DMAP are added. The mixture was stirred at room temperature.

Sources & evidence

ORD record
ord-c9bd6a9deea64c6d93ae00942723d515
Source dataset
uspto-grants-2005_06
Patent number
US06911453B2

Reaction notes

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