Triethylamine → HCID 10141432, compound

HRID 1072676Notes

Reaction equation

HRID 1072676 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:26]=[CH:25][C:13]([O:14][CH:15]([CH3:24])[CH2:16][NH:17][S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.C(N(CC)CC)C.[F:34][C:35]([F:41])([F:40])[S:36](Cl)(=[O:38])=[O:37]>C(Cl)Cl>[CH3:23][CH:21]([S:18]([NH:17][CH2:16][CH:15]([O:14][C:13]1[CH:25]=[CH:26][C:10]([C:7]2[CH:6]=[CH:5][C:4]([CH2:3][NH:2][S:36]([C:35]([F:41])([F:40])[F:34])(=[O:38])=[O:37])=[CH:9][CH:8]=2)=[CH:11][CH:12]=1)[CH3:24])(=[O:20])=[O:19])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 79000Trifluoromethanesulfonyl chlorideHCID 22388582HCID 22388582, compound

Product 1

HCID 10141432HCID 10141432, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The final title compound (23 mg, 11%) was prepared from (2-{4-[4-(aminomethyl)phenyl]phenoxy}propyl)[(methylethyl)sulfonyl]amine hydrochloride (150 mg, 0.430 mmol, prepared in example 32) methylene chloride 2.5 mL, anhydrous) triethylamine (0.07 mL, 0.471 mmol) and trifluoromethylsulfonyl chloride (9.06 mL, 0.565 mmol), in a manner analogous to Example 29.

Sources & evidence

ORD record
ord-3a464d6e860b4802a61377ead5bc6bc3
Source dataset
uspto-grants-2005_06
Patent number
US06911476B2

Reaction notes

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