HCID 22387492, compound → HCID 22387306, compound

HRID 1072759Notes

Reaction equation

HRID 1072759 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36])=[CH:23][CH:22]=3)[C:17]([CH3:20])=[CH:18][CH:19]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.O1CCCC1.[C].[Pd]>[CH2:27]([C:24]1[CH:25]=[CH:26][C:21]([N:16]2[C:17]([CH3:20])=[CH:18][CH:19]=[C:15]2[C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)=[CH:22][CH:23]=1)[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]

Participants

5

Reactant 1

HCID 22387492HCID 22387492, compound

Product 1

HCID 22387306HCID 22387306, compoundYield 93.3%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 2-(4-benzyloxyphenyl)-1-(4-decylphenyl)-5-methyl-1H-pyrrole (2.77 g, 5.77 mmol) in methanol (40 ml) and tetrahydrofuran (40 ml) was added 10% palladium carbon (200 mg) and the mixture was stirred for 4 hours under hydrogen atmosphere. The insoluble matter was filtered out and the filtrate was concentrated to give the object compound as an oily substance. 2.10 g (yield: 93.3%)

Workup

  1. filtrationThe insoluble matter was filtered out
  2. concentrationthe filtrate was concentrated
  3. customto give the object compound as an oily substance

Sources & evidence

ORD record
ord-fa9d888ed9a741bc86271cd21b680b03
Source dataset
uspto-grants-2005_06
Patent number
US06911468B2

Reaction notes

Loading…