反应详情

Methyl 2-chloro-4-(methylthio)benzoate (806 mg) was dropwise added to a suspension of lithium aluminum hydride (139 mg) in tetrahydrofuran (8 ml) under ice-cooling, and the mixture was stirred for 1 hr. The reaction mixture was diluted with ether and 1N hydrochloric acid (10 ml) was dropwise added. The resulting product was extracted three times with ether. The organic layers were combined, washed successively with a saturated aqueous solution of sodium hydrogencarbonate and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the objective compound (725 mg) as a colorless oil.

1. temperaturecooling
2. additionwas dropwise added
3. extractionThe resulting product was extracted three times with ether
4. washwashed successively with a saturated aqueous solution of sodium hydrogencarbonate and saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customThe solvent was evaporated