Hydrogen Bromide → HCID 22387869, compound

Temperature

90 °C

2-Amino-6-chloro-3-nitropyridine (20.2 g) was suspended in a 30% hydrobromide/acetic acid solution (100 ml), and the suspension was stirred at 90° C. After 4 hours, a 30% hydrobromide/acetic acid solution (100 ml) was added, and the mixture was stirred for another 1 hour at 90° C. Then, the reaction mixture was stirred at 100° C. for 8 hr while a hydrobromic acid gas was introduced little by little. The reaction mixture was cooled, and the precipitate was collected by filtration and washed with hexane to give the objective compound (33.0 g) as a pale-yellow powder.

1. stirringthe mixture was stirred for another 1 hour at 90° C
2. additionwas introduced little by little
3. temperatureThe reaction mixture was cooled
4. filtrationthe precipitate was collected by filtration
5. washwashed with hexane

ORD record

ord-758007d56a6347e9a035a1f2f749fb42

Source dataset

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06911469B2