反应详情

3.5 g of 2-hydroxy-4,6-dimethoxypyrimidine, 4.7 g of methyl 2-bromohexanoate, 50 ml of N,N-dimethylformamide and 3.3 g of anhydrous potassium carbonate were stirred at a temperature of from 85° to 90° C. for 3 hours. The reaction mixture was cooled to room temperature and then diluted with water. This aqueous mixture was extracted with ethyl ether. The ethyl ether extract was washed with water and dried. Then, ethyl ether was removed by distillation under reduced pressure to obtain a slightly yellow oily substance. The slightly yellow oily substance was purified by silica gel column chromatography (eluent: hexane/ethyl acetate =6/1) to obtain 4.7 g of the desired product.

1. extractionThis aqueous mixture was extracted with ethyl ether
2. extractionThe ethyl ether extract
3. washwas washed with water
4. customdried
5. customThen, ethyl ether was removed by distillation under reduced pressure
6. customto obtain a slightly yellow oily substance
7. customThe slightly yellow oily substance was purified by silica gel column chromatography (eluent: hexane/ethyl acetate =6/1)