Trifluoroacetic anhydride → HCID 10449715, compound

HRID 1073069Notes

Reaction equation

HRID 1073069 reaction equation
[C:1]([N:18]([CH2:23][C:24]([OH:26])=O)[CH2:19][C:20]([OH:22])=[O:21])([O:3][CH2:4][CH:5]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2)=[O:2].FC(F)(F)C(OC(=O)C(F)(F)F)=O>C(OCC)(=O)C>[C:1]([N:18]1[CH2:23][C:24](=[O:26])[O:22][C:20](=[O:21])[CH2:19]1)([O:3][CH2:4][CH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:12]2[C:17]1=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:2]

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 601361112918-82-8

Product 1

HCID 10449715HCID 10449715, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-FMOC-Iminodiacetic acid (0.40 g, 1.13 mmol) was suspended in 30 ml ethyl acetate and treated with 1 ml of trifluoracetic anhydride. After stirring for one hour, most of the solvent was evaporated. Petroleum ether was added, followed by evaporation, resulting in a solid residue was dried in vacuo at room temperature. The yield was 0.37 g (97%) mp 180°-185° C.

Workup

  1. customwas evaporated
  2. additionPetroleum ether was added
  3. customfollowed by evaporation
  4. customresulting in a solid residue
  5. customwas dried in vacuo at room temperature

Sources & evidence

ORD record
ord-44a902d5d31441a281454669e901d483
Source dataset
uspto-grants-1990_11
Patent number
US04968672

Reaction notes

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